| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Central Michigan ChippewasCMICH | 17 | +988 L | +21.5 (-110) L | O 48.5 (-110) W U 48.5 (-110) L |
| Pittsburgh PanthersPITT | 45 | -1950 W | -21.5 (-110) W |
Pittsburgh Panthers defeated Central Michigan Chippewas 45-17
Pittsburgh Panthers defeated Central Michigan Chippewas 45-17 on September 6, 2025, a 28-point decision in the series. Pittsburgh Panthers' strongest period was the 4th quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Central Michigan Chippewas +21.5 (-110) spread, Pittsburgh Panthers covered, while the 62 combined points finished over the recorded total of 48.5.

