| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Western Kentucky Hilltopperswku | 27 | +120 W | +2.5 (-110) W | O 59 (-110) L U 59 (-110) W |
| Southern Miss. Golden EaglesS.MISS | 16 | -140 L | -2.5 (-110) L |
Western Kentucky Hilltoppers defeated Southern Miss. Golden Eagles 27-16
Western Kentucky Hilltoppers defeated Southern Miss. Golden Eagles 27-16 on December 23, 2025, a 11-point decision in the series. Western Kentucky Hilltoppers' strongest period was the 4th quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Western Kentucky Hilltoppers +2.5 (-110) spread, Western Kentucky Hilltoppers covered, while the 43 combined points finished under the recorded total of 59.
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