Predicting the bills +3 when I seriously think they can win this game outright. They have some old but previous big name running backs who are still vying to be on the depth chart with already Mccoy, Gore & newly drafted Singletary as a lock. I expect more carries for ex rugby player Christian Wade who got to showcase his speed on a lone carry of 65 yards that went for a touchdown in the waining mins of Buffalo's week 1 win against the Indianapolis Colts. Panther's are not slouch as well, especially after their 23-13 victory over the Bears, but their young QB's fighting for back-up rolls going against a viable veteran in Matt Barkley, I'll take the team with the already proven back up against the 2nd and 3rd string teams. Under 40 for point total because of the similarity in schemes and and both have solid defenses that stopped red zone drives in week 1 wins.